The ability of p53 to act as a tumor suppressor is tightly correlated with its ability to function
as a transcriptional activator at the G1/S-phase cell cycle checkpoint. Previous …

Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure
to ionizing radiation. Although repair mechanisms such as homologous recombination and …

The human genome is exposed to many different kinds of DNA‐damaging agents. While
most damage is detected and repaired through complex damage recognition and repair …

Defects in DNA damage responses may underlie genetic instability and malignant
progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma …

NF-κB is an inducible transcription factor, which is regulated by interaction with inhibitory IκB
proteins. Previous studies linked the activity of NF-κB to the proliferative state of the cell …

The ability of low dose ionizing radiation (2 Gy) to modulate the activities of the mitogen
activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) cascades in human …

The transcription factor nuclear factor-κB (NF-κB) is activated in response to various stimuli
including ionizing radiation. Disruption of NF-κB activation by mutant forms of the NF-κB …

NF-κB has been well documented to play a critical role in signaling cell stress reactions. The
extracellular signal-regulated kinase (ERK) regulates cell proliferation and survival …

DNA damage induced by ultraviolet (UV) radiation can be removed by nucleotide excision
repair through two sub-pathways, one general (GGR) and the other specific for transcribed …

NF-κB is a critical nuclear transcriptional factor that is activated in response to cellular
stresses and regulates the expression of genes involved in cell proliferation and cell death …