Control of fate of cells encountered with DNA damaging agents is pivotal for normal cellular
homeostasis. DNA damage leads in many cases to growth arrest of the cells ensuring …

In response to ionizing radiation (IR), cell cycle checkpoints are activated to provide time for
DNA repair. Several different checkpoint mechanisms have been elucidated. However …

The tumor suppressor p53 plays an essential role in cellular adaptation to stress. In
response to ionizing radiation, p53 regulates the transcription of genes in a diverse set of …

Checkpoint adaptation was originally defined in yeast as the ability to divide despite the
presence of damaged DNA. An important unanswered question is whether checkpoint …

The molecular mechanism by which tumor cells increase their resistance to therapeutic
radiation remains to be elucidated. We have previously reported that activation of nuclear …

Cells have evolved elaborate mechanisms (checkpoints) to monitor genomic integrity in
order to ensure the high-fidelity transmission of genetic information. Cells harboring defects …

The Ink4a/Arf (CDKN2a) locus encodes two proteins that regulate distinct important tumor
suppressor pathways represented by p53 and Rb. Loss of either p16INK4a or p19ARF was …

The activity of the tumour suppressor protein p53 is controlled by a balance between E3-
ligase mediated p53 protein degradation and protein kinase-mediated assembly of p53 …

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis,
necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (eg …

Activation of the transcription factor nuclear factor κB (NF-κB) has been implicated in the
protection of cells from apoptosis. We have shown previously that the adenovirus type 5 E1A …