Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Clinical translation of scaffold-based bone tissue engineering (BTE) therapy still faces many
challenges despite intense investigations and advancement over the years. To address …

Bone disorders are of significant concern due to increase in the median age of our
population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

In clinical terms, bone grafting currently involves the application of autogenous, allogeneic,
or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …

For regeneration of highly vascularized and innervated tissues, like bone, simultaneous
ingrowth of blood vessels and nerves is essential but largely neglected. To address this …

Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …

Bone repair and regeneration is a dynamic process that involves a complex interplay
between the (1) ground substance,(2) cells, and (3) milieu. While each constituent is integral …