Lung carcinogenesis is a complex process requiring the acquisition of genetic mutations that
confer the malignant phenotype as well as epigenetic alterations that may be manipulated in …

Introduction: It is reported that cancer may arise in chronically inflamed tissue. There is
mounting evidence suggesting that the connection between inflammation and lung cancer is …

Inflammatory cells and mediators are essential components in tumor microenvironment and
play decisive roles in the initiation, proliferation, survival, promotion, invasion, or metastasis …

Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that
confer cancer development and the malignant phenotype, and is critically linked to …

A number of lines of evidence suggests that chronic inflammation contributes to the process
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …

The inflammatory tumor microenvironment (TME) has many roles in tumor progression and
metastasis, including creation of a hypoxic environment, increased angiogenesis and …

Inflammation is a component of the tumor microenvironment and represents the 7th hallmark
of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

The tumor microenvironment (TME) represents a milieu that enables tumor cells to acquire
the hallmarks of cancer. The TME is heterogeneous in composition and consists of cellular …

Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, it has one
of the lowest 5-year survival rates of all malignancies. With its highly complex mutational …