There are clear links between chronic inflammation and cancer; strong epidemiological and
genetic evidence indicates that inflammation can drive tumour progression, and more-recent …

Despite major improvements in patient management, the prognosis for patients with lung
cancer remains dismal. As our knowledge of the molecular biology of cancers has …

This is the second part of volume Lung Cancer and Personalized Medicine. Part I of this
volume, available as a separate book, discussed lung cancer as a disease, the available …

Over the past 100 years, our understanding of the pathogenesis of lung cancer has
advanced impressively. Environmental carcinogens and a gene locus determining …

Inflammatory mediators in tumor microenvironment influence cancer occurrence, growth and
metastasis through complex signaling networks. Excessive inflammation is closely …

Epigenetic disorders such as point mutations in cellular tumor suppressor genes, DNA
methylation and post-translational modifications are needed to transformation of normal …

The link between chronic immune activation and tumorigenesis is well established.
Compelling evidence has accumulated that histologic assessment of infiltration patterns of …

The lung is a highly specialized organ that facilitates uptake of oxygen and release of
carbon dioxide. Due to its unique structure providing enormous surface area to outside …

Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The
linkage between inflammation and cancer, first perceived in the nineteenth century, is now …

Both lung cancer and chronic obstructive pulmonary disease (COPD) are associated with
cigarette smoking, which, by generating reactive oxidant species, induces a chronic …