Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis

A Nishiguchi, T Taguchi - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by
immune system dysfunction. Despite the availability of various anti-inflammatory drugs, they …

ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

M Bao, K Wang, J Li, Y Li, H Zhu, M Lu, Y Zhang… - Acta Biomaterialia, 2023 - Elsevier
Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …

Apigenin-Mn (II) loaded hyaluronic acid nanoparticles for ulcerative colitis therapy in mice

F Lv, Y Zhang, Q Peng, X Zhao, D Hu, J Wen… - Frontiers in …, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease characterized by
rapid progression and frequent comorbidities that make its treatment challenging …

Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis

A Nishiguchi, T Taguchi - Advanced Functional Materials, 2021 - Wiley Online Library
Modulation of innate immune responses is a potential strategy for treating inflammatory
diseases. Although biogenic polyamines are known as immunomodulatory compounds …

Reactive oxygen species-responsive polyether micelle nanomaterials for targeted treatment of ulcerative colitis

XX Zhao, SB Ma, JP Wen, DT Hu… - Journal of …, 2022 - ingentaconnect.com
As one of the most challenging inflammatory diseases, the incidence of ulcerative colitis
(UC) is increasing year by year, but the existing therapeutic drugs are not effective and lack …

Curcumin nanocrystal/pH-responsive polyelectrolyte multilayer core–shell nanoparticles for inflammation-targeted alleviation of ulcerative colitis

MA Oshi, J Lee, M Naeem, N Hasan, J Kim… - …, 2020 - ACS Publications
In this study, we developed oral core–shell nanoparticles composed of curcumin
nanocrystals in the core and chitosan/alginate multilayers in the shell for inflammation …

ROS responsive polydopamine nanoparticles to relieve oxidative stress and inflammation for ameliorating acute inflammatory bowel

M Yan, L Zhu, S Wu, Y Cao, N Mou, Q Chi, G Wang… - Biomaterials …, 2022 - Elsevier
Oxidative stress is a key factor in the development of inflammatory diseases. Elimination of
reactive oxygen species (ROS) in the inflamed colon has been confirmed as an effective …

Alpha‐tocopheryl succinate‐conjugated G5 PAMAM dendrimer enables effective inhibition of ulcerative colitis

Y Wang, W Shen, X Shi, F Fu, Y Fan… - Advanced …, 2017 - Wiley Online Library
Ulcerative colitis (UC) is a severe inflammatory disease in colon, however, the therapeutic
efficacy of the standard‐of‐care in clinic for UC patients is unsatisfactory. To explore new …

Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair

F Lei, F Zeng, X Yu, Y Deng, Z Zhang, M Xu… - Journal of …, 2023 - Springer
Background Due to oral nano-delivery systems for the treatment of inflammatory bowel
disease (IBD) are often failed to accumulated to the colonic site and could not achieve …

Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Z Le, Z He, H Liu, J Ke, L Liu, Z Liu, Y Chen - Biomaterials Science, 2022 - pubs.rsc.org
Colorectal cancer is the third most common malignancy that leads to significant mortality
around the world. Chronic colonic inflammation could induce a protumor effect by the …