One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology
The transition from acute to chronic pain is an ongoing major problem for individuals, society
and healthcare systems around the world. It is clear chronic pain is a complex …
and healthcare systems around the world. It is clear chronic pain is a complex …
The interplay between chronic pain, opioids, and the immune system
V Malafoglia, S Ilari, L Vitiello, M Tenti… - The …, 2022 - journals.sagepub.com
Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …
both social and economic costs, often causing severe and intractable physical and …
[HTML][HTML] Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions
I Zouikr, B Karshikoff - Frontiers in immunology, 2017 - frontiersin.org
Chronic pain is a debilitating condition that still is challenging both clinicians and
researchers. Despite intense research, it is still not clear why some individuals develop …
researchers. Despite intense research, it is still not clear why some individuals develop …
Neuroimmune interactions in chronic pain–an interdisciplinary perspective
Z Hore, F Denk - Brain, behavior, and immunity, 2019 - Elsevier
It is widely accepted that communication between the nervous and immune systems is
involved in the development of chronic pain. At each level of the nervous system, immune …
involved in the development of chronic pain. At each level of the nervous system, immune …
[HTML][HTML] The role of neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance
M Echeverria-Villalobos, V Tortorici, BE Brito… - Frontiers in …, 2023 - frontiersin.org
Current evidence suggests that activation of glial and immune cells leads to increased
production of proinflammatory mediators, creating a neuroinflammatory state …
production of proinflammatory mediators, creating a neuroinflammatory state …
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids …
clinical research was directed at the study of stereoselective neuronal actions of opioids …
[HTML][HTML] Cytokines in pain: harnessing endogenous anti-inflammatory signaling for improved pain management
AG Vanderwall, ED Milligan - Frontiers in immunology, 2019 - frontiersin.org
Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …
Immune regulation of pain: Friend and foe
A Kavelaars, CJ Heijnen - Science translational medicine, 2021 - science.org
The immune system and the peripheral sensory nervous system communicate through
hardwired and humoral routes using shared mediators and receptors. On the basis of …
hardwired and humoral routes using shared mediators and receptors. On the basis of …
[HTML][HTML] Immune drivers of physiological and pathological pain
Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …
Crosstalk between the nociceptive and immune systems in host defence and disease
Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …
There is growing evidence for bidirectional signalling between these two systems, and the …