CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways

H Xu, J Wang, M Al‐Nusaif, H Ma, W Le - Cell Proliferation, 2024 - Wiley Online Library
In non‐small cell lung cancer (NSCLC), metastasis is the most common phenotype, and
autophagy plays a vital role in its regulation. However, there are limited data on how …

[HTML][HTML] CCR10/CCL27 crosstalk regulates cell metastasis via PI3K-Akt signaling axis in non-small-cell lung cancer

Y Liu, A Xiao, B Zhang - American Journal of Translational …, 2021 - ncbi.nlm.nih.gov
Previous research has shown that CCR10 acts as a vital oncogene in the progression of
multiple malignancies. However, its effect on the treatment of non-small-cell lung cancer …

CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner

Y Niu, D Tang, L Fan, W Gao… - Experimental and …, 2020 - spandidos-publications.com
The CC chemokine receptor 9 (CCR9) and its natural secreted ligand CC motif chemokine
ligand 25 (CCL25) have been implicated in cancer metastasis. However, their metastatic …

[HTML][HTML] Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells

J An, Y Xue, M Long, G Zhang, J Zhang, H Su - Oncotarget, 2017 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, which is the
leading cancer killer in the world. Despite the recent advances in its diagnosis and therapy …

CCL5 increases lung cancer migration via PI3K, Akt and NF-κB pathways

CY Huang, YC Fong, CY Lee, MY Chen, HC Tsai… - Biochemical …, 2009 - Elsevier
CCL5 (previously called RANTES) is in the CC-chemokine family and plays a crucial role in
the migration and metastasis of human cancer cells. Besides, integrins are the major …

CCR1 knockdown suppresses human non-small cell lung cancer cell invasion

CL Wang, BS Sun, Y Tang, HQ Zhuang… - Journal of cancer research …, 2009 - Springer
Purpose CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of
leukocytes to the site of inflammation. Tumor invasion and metastasis share many …

Overexpression of RCC2 enhances cell motility and promotes tumor metastasis in lung adenocarcinoma by inducing epithelial–mesenchymal transition

B Pang, N Wu, R Guan, L Pang, X Li, S Li, L Tang… - Clinical Cancer …, 2017 - AACR
Purpose: Investigate the role of regulator of chromosome condensation 2 (RCC2) on lung
adenocarcinoma (LUAD) metastasis. Experimental Design: Clinical specimens were used to …

CCR9–CCL25 interaction suppresses apoptosis of lung cancer cells by activating the PI3K/Akt pathway

B Li, Z Wang, Y Zhong, J Lan, X Li, H Lin - Medical Oncology, 2015 - Springer
Abstract CC chemokine receptor-9 (CCR9) is highly expressed in non-small cell lung cancer
(NSCLC) tissues and cell lines. However, the biological functions and the signals elicited by …

[HTML][HTML] CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion

Y Meng, L Yang, X Wei, H Luo, Y Hu, X Tao… - Biochemical and …, 2021 - Elsevier
Abstract Cyclin D1 (CCND1) has been identified as a metastatic promoter in various tumors
including lung adenocarcinoma (LUAD), a subtype of non small cell lung cancer (NSCLC) …

Production of CCL 20 from lung cancer cells induces the cell migration and proliferation through PI 3K pathway

B Wang, L Shi, X Sun, L Wang… - Journal of cellular and …, 2016 - Wiley Online Library
Tumour inflammatory microenvironment is considered to play a role in the sensitivity of
tumour cells to therapies and prognosis of patients with lung cancer. The expression of CCL …