In eukaryotic cells, PA2 is a central precursor for the synthesis of major
glycerophospholipids, DAG and TAG, as well as a major signaling lipid. In mammalian cells …

Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that
involves regulation by both genetic and biochemical mechanisms. The activity levels of …

The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes
membrane phospholipids by pathways that are generally common to those found in higher …

In the yeast Saccharomyces cerevisiae, the synthesis of phospholipids in the exponential
phase of growth occurs at the expense of the storage lipid triacylglycerol. As exponential …

The PAH1-encoded phosphatidate phosphatase (PAP), which catalyzes the committed step
for the synthesis of triacylglycerol in Saccharomyces cerevisiae, exerts a negative regulatory …

The last several years have been witness to significant developments in understanding
transcriptional regulation of the yeast phospholipid structural genes. The response of most …

In the yeast Saccharomyces cerevisiae, the synthesis of phospholipids is coordinately
regulated by mechanisms that control the homeostasis of the essential mineral zinc …

Diacylglycerol pyrophosphate (DGPP) is a novel phospholipid that has been found in plants
and yeast but not in higher animals. It is produced through phosphorylation of phosphatidic …

In yeast and higher eukaryotes, phospholipids and triacylglycerol are derived from
phosphatidate at the nuclear/endoplasmic reticulum membrane. In de novo biosynthetic …

In the yeast Saccharomyces cerevisiae lipid particles harbor two acyltransferases, Gat1p
and Slc1p, which catalyze subsequent steps of acylation required for the formation of …