Prognostic Significance and Clinicopathological Associations of COX‐2 SNP in Patients with Nonsmall Cell Lung Cancer

PP Grimminger, J Stöhlmacher… - Journal of …, 2009 - Wiley Online Library
Background. To further improve the screening, diagnosis, and therapy of patients with
nonsmall cell lung cancer (NSCLC) additional diagnostic tools are urgently needed. Gene …

Prognostic value of cyclooxygenase‐2 gene polymorphisms in advanced non‐small cell lung cancer patients treated with first‐line platinum‐based chemotherapy

L Liu, F Zhou, S Ren, X Chen, X Li… - Asia‐Pacific Journal of …, 2016 - Wiley Online Library
Abstract Aim Cyclooxygenase‐2 (COX‐2) plays an important role in cell apoptosis,
angiogenesis and tumor invasion, and over‐expression of COX‐2 is associated with tumor …

Functional analysis of polymorphisms in the COX‑2 gene and risk of lung cancer

JL Moraes, AB Moraes, V Aran… - Molecular and …, 2017 - spandidos-publications.com
Abstract The enzyme cyclooxygenase 2 (COX‑2) is known to be involved in tumorigenesis
and metastasis in certain types of cancer. Nevertheless, the prognostic value of COX‑2 …

Cyclooxygenase-2 Genetic Variants Are Associated with Survival in Unresectable Locally Advanced Non–Small Cell Lung Cancer

N Bi, M Yang, L Zhang, X Chen, W Ji, G Ou, D Lin… - Clinical cancer …, 2010 - AACR
Abstract Purpose: Cyclooxygenase-2 (COX-2) plays important roles in the modulation of
apoptosis, angiogenesis, immune response, and tumor invasion. Elevated COX-2 …

Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer

J Brabender, JM Park, R Metzger, PM Schneider… - Annals of …, 2002 - journals.lww.com
Objective To investigate cyclooxygenase-2 (COX-2) mRNA expression in curatively resected
non-small cell lung cancer (NSCLC) and to determine its association with prognosis …

[HTML][HTML] Association between COX-2 polymorphisms and non-small cell lung cancer susceptibility

T Zhang, J Li, T Xia, N Zhang, Y Zhang… - International Journal of …, 2015 - ncbi.nlm.nih.gov
Aim: To explore the association between COX-2 polymorphisms and non-small cell lung
cancer (NSCLC) susceptibility. Methods: We collected fasting peripheral venous blood from …

COX-2 overexpression and-8473 T/C polymorphism in 3′ UTR in non-small cell lung cancer

IA Bhat, R Rasool, I Qasim, KZ Masoodi, SA Paul… - Tumor Biology, 2014 - Springer
A new class of compounds targeting cyclooxygenase 2 (COX-2) together with other different
clinically used therapeutic strategies has recently shown a promise for the chemoprevention …

[HTML][HTML] Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis

P Zhan, Q Qian, LK Yu - Journal of thoracic disease, 2013 - ncbi.nlm.nih.gov
Background Cyclooxygenase-2 (COX-2) has been implicated in tumorigenesis and
metastasis, and it presumably mediates the proliferation of endothelial cells and promotes …

Prognostic significance of cyclooxygenase 2 expression in 259 cases of non–small cell lung cancer

AC Laga, DS Zander, PT Cagle - Archives of pathology & …, 2005 - meridian.allenpress.com
Context.—Previous studies report that increased expression of cyclooxygenase 2 (COX-2)
correlates with poor clinical outcome in several malignancies, including non–small cell lung …

Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer

H Tsubochi, N Sato, M Hiyama, M Kaimori… - The Annals of thoracic …, 2006 - Elsevier
BACKGROUND: Cyclooxygenase-2 (COX-2) is known to play a role in carcinogenesis and
tumor progression. The aim of this study was to evaluate the relationship between COX-2 …