This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

Objective To investigate the endogenous involvement of transient receptor potential
vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse. Methods Following …

Objective To determine whether activation of transient receptor potential vanilloid 4 (TRPV‐
4) induces inflammation in the rat temporomandibular joint (TMJ), and to assess the effects …

The transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel, which
is mainly expressed by nociceptive neurons in dorsal root and trigeminal ganglia. However …

Transient receptor potential vanilloid (TRPV) 4 belongs to the TRPV subfamily of TRP ion
channels. TRPV4 channels play a critical role in chondrocytes and thus TRPV4 is an …

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide.
Despite its prevalence, our understanding of the underlying mechanisms remains …

The Transient Receptor Potential Vanilloid 1 (TRPV1R) is a ligand-gated, non-selective
cation channel expressed predominantly by sensory neurons. TRPV1Rs respond to a …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

Biomechanical factors play a critical role in regulating the physiology as well as the
pathology of multiple joint tissues and have been implicated in the pathogenesis of …

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …