The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

The development of tissue engineering strategies for treatment of large bone defects has
become increasingly relevant, given the growing demand for bone substitutes. Native bone …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …

The functional regeneration of thick vascularized tissues such as bone and muscle is
complicated by the large volume of lost tissue, challenging biomechanical environment, and …

Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …