Expression of the chemokine receptor CXCR4 has been linked with increased metastasis
and decreased clinical prognosis in breast cancer. The current paradigm dictates that …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …

Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …

Background A growing body of work implicates chemokines, in particular CXCL12 and its
receptors, in the progression and site-specific metastasis of various cancers, including …

Compelling evidence shows that chemokine CXC motif chemokine ligand 12 (CXCL12)
drives metastasis in multiple malignancies. Similar to other key cytokines in cancer, CXCL12 …

There is growing evidence that several chemokine receptors including CXCR3 contribute to
metastasis of breast and other cancers, however, in order to target CXCR3 effectively, it is …

Chemokine CXCL12 and receptor CXCR4 control multiple steps in primary tumor growth
and metastasis in breast cancer and more than 20 other human malignancies. Mechanisms …

Breast cancer is one of the leading causes of cancer related deaths worldwide. Breast
cancer-related mortality is associated with the development of metastatic potential of primary …

Chemokines comprise a superfamily of at least 46 cytokines that were initially described
based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed …