[HTML] nih.gov

COX-2 inhibitors decrease expression of PD-L1 in colon tumors and increase the influx of type I tumor-infiltrating lymphocytes

DL Cecil, EA Gad, LR Corulli, N Drovetto… - Cancer Prevention …, 2022 - AACR
Colon cancer is initiated under inflammatory conditions associated with upregulation of
immune checkpoint proteins. We evaluated immune modulation induced by nonsteroidal …
被引用次数：14 相关文章 所有 6 个版本
[HTML] nih.gov

The COX-2–PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas

J Wei, J Zhang, D Wang, B Cen, JD Lang… - Cancer Prevention …, 2022 - AACR
The mechanisms underlying the regulation of a checkpoint receptor, PD-1, in tumor-
infiltrating immune cells during the development of colorectal cancer are not fully …
被引用次数：29 相关文章 所有 6 个版本
[HTML] nih.gov

[HTML][HTML] Aspirin use and colorectal cancer survival according to tumor CD274 (programmed cell death 1 ligand 1) expression status

T Hamada, Y Cao, ZR Qian, Y Masugi… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint
pathway can improve clinical outcomes in various malignancies. Evidence suggests that …
被引用次数：143 相关文章 所有 10 个版本
[PDF] wiley.comFull View

Upregulation of PD‐1 follows tumour development in the AOM/DSS model of inflammation‐induced colorectal cancer in mice

M Yassin, Z Sadowska, D Djurhuus, B Nielsen… - …, 2019 - Wiley Online Library
Chronic inflammation may drive development of cancer as observed in inflammation‐
induced colorectal cancer (CRC). Though immune cells can infiltrate the tumour …
被引用次数：35 相关文章 所有 7 个版本
[HTML] tandfonline.comFull View

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

M Dosset, TR Vargas, A Lagrange, R Boidot… - …, 2018 - Taylor & Francis
Background: Chemotherapy is currently evaluated in order to enhance the efficacy of
immune checkpoint blockade (ICB) therapy in colorectal cancer. However, the mechanisms …
被引用次数：190 相关文章 所有 14 个版本
[PDF] iiarjournals.orgFree from Publisher

Impact of COX2 inhibitor for regulation of PD-L1 expression in non-small cell lung cancer

K Shimizu, R Okita, S Saisho, AI Maeda… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: There is no clear evidence in the literature regarding the regulation of
programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this …
被引用次数：27 相关文章 所有 5 个版本

Nimesulide inhibits IFN-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms

M Liang, H Yang, J Fu - Cancer letters, 2009 - Elsevier
It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface
expression in cancer cells and the resultant T cell suppression contribute to cancer cell …
被引用次数：47 相关文章 所有 8 个版本
[HTML] springer.comFull View

[HTML][HTML] COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

G Botti, F Fratangelo, M Cerrone, G Liguori… - Journal of Translational …, 2017 - Springer
Background The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have
prompted investigators to implement novel clinical trials which combine immunotherapy with …
被引用次数：100 相关文章 所有 18 个版本
[HTML] nih.gov

[HTML][HTML] Targeting interleukin-6 (IL-6) sensitizes anti-PD-L1 treatment in a colorectal cancer preclinical model

J Li, J Xu, X Yan, K Jin, W Li… - Medical science monitor …, 2018 - ncbi.nlm.nih.gov
Background Limited efficacy of immune checkpoint blockades was observed in clinical trials
in colorectal (CRC) patients, especially in the microsatellite-stable patients. Interleukin-6 (IL …
被引用次数：73 相关文章 所有 7 个版本

Interleukin-6 is potential target to de-couple checkpoint inhibitor-induced colitis from antitumor immunity.

DH Johnson, Y Hailemichael, WC Foo, KR Hess… - 2019 - ascopubs.org
2616 Background: A deep understanding of the immunobiology of checkpoint inhibitor (CPI)
induced immune related toxicities, such as immune related enterocolitis (irEC), and how …
被引用次数：9 相关文章