Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme activity have shown
chemopreventive activity in carcinogen-induced and transgenic rodent tumor models and …

Chronic inflammation is a risk factor for several different cancers including colorectal cancer
(CRC). However, the mechanisms underlying the contribution of inflammation to cancer …

Abstract 4761 Background: There is evidence that the PD-1 (programmed death 1)/PD-L1
signaling pathway is an important mechanism for tumors to evade T cell recognition in …

Both nonneoplastic colon epithelium and colon carcinoma cells in situ are continuously
exposed to lipopolysaccharide (LPS). Few reports have addressed possible direct effects of …

Inflammation is associated with the development and malignant progression of most
cancers. As most of the cell types involved in cancer-associated inflammation are genetically …

Compared with prostaglandin E2, which has an established role in cancer, the role of the
COX metabolite prostaglandin D2 (PGD2) in chronic inflammation leading to tumorigenesis …

Mounting evidence from preclinical and clinical studies suggests that persistent
inflammation functions as a driving force in the journey to cancer. Cyclooxygenase-2 (COX …

Introduction: In the tumor microenvironment, interferon gamma (IFN-γ) secreted by tumor
infiltrating lymphocytes can upregulate programmed cell death 1 ligand 1 (PD-L1) …

Background Colon cancer is a common digestive tract malignancy which ranks as the third
leading cause of cancer death worldwide. A current focus of anti-cancer research is …

Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …