Cyclooxygenase-2 is frequently overexpressed and associated with poor prognosis in
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …

Abstract Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated
with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 …

It is well established that high cyclooxygenase-2 (COX-2) expression contributes to the
aggressive behavior of breast and other malignancies. Due to concerns regarding the safety …

Abstract Cyclooxygenase-2 (COX-2) is associated with aggressive breast cancers. The COX-
2 product prostaglandin E 2 (PGE 2) acts through four G-protein-coupled receptors …

Abstract Prostaglandin E2 (PGE2), one of the major metabolites of cyclooxygenase-2, has
been implicated in tumorigenesis and tumor progression in several human cancers …

Prostaglandins are lipid compounds that mediate many physiological effects. Prostaglandin
E2 (PGE 2) is the most abundant prostanoid in the human body, and synthesis of PGE 2 is …

Cyclooxygenase enzymes play an important role in carcinogenesis, and increased
expression of cyclooxygenase enzymes has been reported in cancers arising at a number of …

Background In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated
prostaglandin (PG) E2 synthesis have been associated with tumor development and …

Cyclooxygenase (COX)‐2 is known to correlate with poor cancer prognosis and to contribute
to tumor metastasis. However, the precise mechanism of this phenomenon remains …

Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast
cancer (LABC) characterized by rapid growth and aggressive invasion with no selective …