Tubulin is a validated target for antitumor drugs. However, the effectiveness of these
microtubule-interacting agents is limited by the fact that they are substrates for drug efflux …

The feasibility of combined studies on a cell-line panel and primary cultures of patient tumor
cells in the preclinical evaluation of new anticancer drugs was evaluated in a study of the …

Purpose: Vinflunine (VFL) is a novel Vinca alkaloid with markedly superior experimental in
vivo antitumour activity to its parent molecule, vinorelbine (Navelbine, NVB), against a panel …

Inostamycin, a novel polyether compound, reverses multidrug resistance in KB cells. The
mechanism of its action was studied by use of radioactively labeled vinblastine. Inostamycin …

Rhizoxin is a tubulin-binding cytotoxic compound, isolated from the fungus Rhizopus
chinensis, with significant antineoplastic activity in several murine and human tumor models …

Vincristine is known as an effective agent for chemotherapy of neoplastic diseases. Its main
pharmacological activity is known to be linked to its inhibition of microtubule dynamics …

Abstract RS-1541 is a 13-O-palmitoyl derivative of rhizoxin, an inhibitor of tubulin
polymerization. After intravenous administration of RS-1541 to mice bearing M5076 …

The multidrug resistance modifying activity of a dithiane analogue of tiapamil, Ro 44-5912,
was examined in vivo. Results of acute toxicity studies in mice indicated that lethal toxicity …

Abstract BACKGROUND Oncoprotein 18 (op18) was first isolated as a molecule
overexpressed in several malignant cells, suggesting a function of op18 in malignant …

Vinflunine (VFL) is a novel derivative of vinorelbine (NVB, Navelbine®), which has shown
markedly superior antitumor activity to NVB, in various experimental animal models. To …