Rel/NF-kB transcription factors include a collection of proteins, conserved from Drosophila to
humans (Figure 1). Among model organisms, these transcription factors are notably absent …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

Publisher Summary This chapter highlights NF-кB/Rel protein complex. Associations of the
binding and regulatory subunits of NF-кB operate at the center of a variety of different signal …

of the NF-κB dimer which then translocates to the nucleus to activate gene transcription. In
the case of IκBα the inducible phosphorylation sites were mapped to serines (S) 32 and 36 …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

It is not often that a problem in biology is so well defined and yet so elusive. Just a decade
ago, David Baltimore and colleagues reported the identification of a nuclear factor that …

The sequence and biochemical properties of the prod-Nuct of the cloned cDNA for the~ 65
subunit of nuclear, factor KB (NF-KB) have been determined. The cDNA has an open …

A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

The NF-κB family of transcription factors plays a crucial role in the immune, inflammatory and
apoptotic responses. These proteins are normally found in the cytoplasm, retained by …

NF-κB is activated by various stimuli including inflammatory cytokines and stresses. A key
step in the activation of NF-κB is the phosphorylation of its inhibitors, IκBs, by an IκB kinase …