Overexpression of cyclooxygenase-2 (COX-2) is frequently presentin lung cancer and may
play a significant role in carcinogenesis, invasion, and metastasis. It has been associated …

Background Cyclooxygenase-2 (COX-2) has been implicated in tumorigenesis and
metastasis, and it presumably mediates the proliferation of endothelial cells and promotes …

Evaluation of: Tsubochi H, Nobuyuki S, Hiyama M et al.: Combined analysis of
cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. Ann. Thorac …

BACKGROUND: We investigated the prognostic value of cyclooxygenase-2 (COX-2) for
survival of patients with non-small cell lung cancer (NSCLC). METHODS: We performed a …

Purpose Overexpression of COX-2 correlates with advanced stage and worse outcomes in
non–small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2 …

Non-small cell lung Cancer (NSCLC) is extremely resistant to chemotherapeutic agents,
such as cisplatin. High expression of the inflammatory enzyme Cyclooxygenase-2 (COX-2) …

BACKGROUND: Human lung cancer is a major cause of death worldwide with few known
effective therapeutic modalities. The isoenzyme cyclooxygenase 2 (COX-2) is an inducible …

The most common and leading cause of cancer-related death in men is lung cancer. Despite
the recent advances in chemotherapy, advanced lung cancer still remains incurable. For …

BACKGROUND Cyclooxygenase (Cox) is the main target enzyme for the nonsteroidal
antiinflammatory drugs that have been shown to suppress carcinogenesis in both …

Background The study of cyclooxygenase-2 (COX-2) inhibitors is now mired in controversy.
We performed a meta-analysis to assess the efficacy and safety profile of COX-2 inhibitors in …