Roles of a prostaglandin E‐type receptor, EP3, in upregulation of matrix metalloproteinase‐9 and vascular endothelial growth factor during enhancement of tumor …
H Amano, Y Ito, T Suzuki, S Kato, Y Matsui… - Cancer …, 2009 - Wiley Online Library
Cyclooxygenase (COX)‐2 is known to correlate with poor cancer prognosis and to contribute
to tumor metastasis. However, the precise mechanism of this phenomenon remains …
to tumor metastasis. However, the precise mechanism of this phenomenon remains …
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent …
M Dohadwala, RK Batra, J Luo, Y Lin, K Krysan… - Journal of Biological …, 2002 - ASBMB
Tumor cyclooxygenase-2 (COX-2) expression is known to be associated with enhanced
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …
tumor invasiveness. In the present study, we evaluated the importance of the COX-2 product …
Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism
L Yang, Y Huang, R Porta, K Yanagisawa, A Gonzalez… - Cancer research, 2006 - AACR
Abstract Prostaglandin E2 (PGE2), one of the major metabolites of cyclooxygenase-2, has
been implicated in tumorigenesis and tumor progression in several human cancers …
been implicated in tumorigenesis and tumor progression in several human cancers …
Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities
X Ma, N Kundu, OB Ioffe, O Goloubeva, R Konger… - Molecular Cancer …, 2010 - AACR
Cyclooxygenase-2 is frequently overexpressed and associated with poor prognosis in
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …
Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis
Abstract Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated
with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 …
with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 …
Prostaglandin E2 receptor EP 4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem‐like cell …
M Majumder, X Xin, L Liu, GV Girish, PK Lala - Cancer science, 2014 - Wiley Online Library
We previously established that COX‐2 overexpression promotes breast cancer progression
and metastasis. As long‐term use of COX‐2 inhibitors (COX‐2i) can promote thrombo …
and metastasis. As long‐term use of COX‐2 inhibitors (COX‐2i) can promote thrombo …
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation
J Jiang, R Dingledine - Journal of Pharmacology and Experimental …, 2013 - ASPET
Population studies, preclinical, and clinical trials suggest a role for cyclooxygenase-2 (COX-
2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor …
2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor …
Prostaglandin E2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells
H Fujino, K Toyomura, X Chen, JW Regan… - Biochemical …, 2011 - Elsevier
An important event in the development of tumors is angiogenesis, or the formation of new
blood vessels. Angiogenesis is also known to be involved in tumor cell metastasis and is …
blood vessels. Angiogenesis is also known to be involved in tumor cell metastasis and is …
Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth
H Amano, I Hayashi, H Endo, H Kitasato… - The Journal of …, 2003 - rupress.org
Nonsteroidal antiinflammatories are known to suppress incidence and progression of
malignancies including colorectal cancers. However, the precise mechanism of this action …
malignancies including colorectal cancers. However, the precise mechanism of this action …
EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival
Abstract Prostaglandin E2 (PGE 2), a major cyclooxygenase (COX) metabolite, plays
important roles in tumor biology. We studied the role of EP2, a receptor for PGE 2, in tumor …
important roles in tumor biology. We studied the role of EP2, a receptor for PGE 2, in tumor …