Abstract Prostaglandin E2 (PGE2), one of the major metabolites of cyclooxygenase-2, has
been implicated in tumorigenesis and tumor progression in several human cancers …

Cyclooxygenase (COX)‐2 is known to correlate with poor cancer prognosis and to contribute
to tumor metastasis. However, the precise mechanism of this phenomenon remains …

Cyclooxygenase-2 is frequently overexpressed and associated with poor prognosis in
breast cancer. The cyclooxygenase-2 product prostaglandin E2 elicits cellular responses …

Abstract Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated
with a poor prognosis. In a murine model of metastatic breast cancer, we showed that COX-2 …

Population studies, preclinical, and clinical trials suggest a role for cyclooxygenase-2 (COX-
2, PTGS2) in tumor formation and progression. The downstream prostanoid receptor …

Abstract Cyclooxygenase-2 and prostaglandin E2 (PGE2) levels are increased in colorectal
cancers and a subset of adenomas. PGE2 signaling through the EP4 receptor has …

The predominant product of cyclooxygenase (COX) activity in the colon, prostaglandin (PG)
E 2 promotes intestinal tumorigenesis. Expression of the PGE 2 receptor EP4 is upregulated …

It is well established that high cyclooxygenase-2 (COX-2) expression contributes to the
aggressive behavior of breast and other malignancies. Due to concerns regarding the safety …

Abstract Prostaglandin E2 (PGE 2), a major cyclooxygenase (COX) metabolite, plays
important roles in tumor biology. We studied the role of EP2, a receptor for PGE 2, in tumor …

Background: Manipulating prostaglandin (PG) production modulates tumor development.
Elevated PGI 2 production prevents murine lung cancer, while decreasing PGE 2 content …