Breast cancer is one of the leading causes of cancer deaths among females. Many
challenges exist in the current management of advanced stage breast cancer as there are …

Breast cancer is characterized by a distinct metastatic pattern involving the regional lymph
nodes, bone marrow, lung and liver. Tumour cell migration and metastasis share many …

The chemokine-CXCL12 and its receptor, CXCR4, have recently been shown to play an
important role in regulating the directional migration of breast cancer cells to sites of …

CXCR4, the receptor for stromal cell-derived factor-1 (SDF-1), belongs to the chemokine
receptor family and has been shown to play an important role in regulating the directional …

Background The stromal cell-derived factor-1/CXC chemokine receptor-4 (SDF-1/CXCR4)
signal has been shown to be important in various immunological reactions. Recent studies …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …

The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-
) biological networks including malignancies. However, except for CXCR4/CXCL12, little is …

Interactions between chemokines and chemokine receptors have been proposed recently to
be of importance in the development and progression of cancer. Human breast cancer cells …

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its
mechanism in initiating distant metastasis is not well understood. Here, we generated a …

BACKGROUND: CXCL12/CXCR4 signaling may be involved in tumor growth and
angiogenesis, and homing of cancer cells to bone and other organs. Our purpose was to …