CXC motif chemokine 12/CXC chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment
Introduction Although CXC motif chemokine 12 (CXCL12) has been shown to bind to CXC
chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by …
chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by …
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
N Salazar, D Muñoz, G Kallifatidis, RK Singh, M Jordà… - Molecular cancer, 2014 - Springer
Background Recent advances have revealed a significant contribution of chemokines and
their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis …
their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis …
Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
J Wang, L He, CA Combs, G Roderiquez… - Molecular cancer …, 2006 - AACR
Abstract Chemokine receptor CXCR4 (CD184) may play a role in cancer metastasis and is
known to form homodimers. However, it is not clear how transmembrane regions (TM) of …
known to form homodimers. However, it is not clear how transmembrane regions (TM) of …
The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study
O Salvucci, A Bouchard, A Baccarelli… - Breast cancer research …, 2006 - Springer
The chemokine receptor CXCR4 is an important factor in the migration, invasiveness,
metastasis and proliferation of breast cancer cells. We have retrospectively analyzed the …
metastasis and proliferation of breast cancer cells. We have retrospectively analyzed the …
Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes
K Kawada, H Hosogi, M Sonoshita, H Sakashita… - Oncogene, 2007 - nature.com
Chemokines and their receptors are essential for leukocyte trafficking, and also implicated in
cancer metastasis to specific organs. We have recently demonstrated that CXCR3 plays a …
cancer metastasis to specific organs. We have recently demonstrated that CXCR3 plays a …
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti‐VEGF treatment or docetaxel in a transgenic mouse …
S Hassan, M Buchanan, K Jahan… - … journal of cancer, 2011 - Wiley Online Library
CXCR4 is a chemokine receptor implicated in the homing of cancer cells to target metastatic
organs, which overexpress its ligand, stromal cell‐derived factor (SDF)‐1. To determine the …
organs, which overexpress its ligand, stromal cell‐derived factor (SDF)‐1. To determine the …
Homeostatic chemokine receptors and organ-specific metastasis
A Zlotnik, AM Burkhardt, B Homey - Nature Reviews Immunology, 2011 - nature.com
It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer
metastasis was first documented. Since then, the field of chemokines and cancer has grown …
metastasis was first documented. Since then, the field of chemokines and cancer has grown …
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
LJ Drury, JJ Ziarek, S Gravel… - Proceedings of the …, 2011 - National Acad Sciences
Chemokines and chemokine receptors are extensively and broadly involved in cancer
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
C Ginestier, S Liu, ME Diebel… - The Journal of …, 2010 - Am Soc Clin Investig
Recent evidence suggests that breast cancer and other solid tumors possess a rare
population of cells capable of extensive self-renewal that contribute to metastasis and …
population of cells capable of extensive self-renewal that contribute to metastasis and …