Abstract Introduction Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast
cancer, correlating with a poor prognosis. Researchers in previous studies who used the …

Hormone refractory metastatic prostate cancer remains an incurable disease. We found that
high expression levels of the chemokine receptor CXCR4 correlated with the presence of …

Metastasis is considered the obvious mark for most aggressive cancers. However, little is
known about the molecular mechanism of the regulation of cancer metastasis. Recent …

The cytokine CXC motif chemokine 12 (CXCL12) is synthesised by metastasis target tissues
and has been shown to attract tumour cells that express the receptor, CXC chemokine …

The chemotactic cytokines called chemokines are a superfamily of small secreted cytokines
that were initially characterized through their ability to prompt the migration of leukocytes …

Chemokine receptor CXCR4 and its ligand CXCL12 are suggested to be involved in
migration, invasion and metastasis of breast cancer cells. Mutation of the tumor suppressor …

Chemokines and their receptors play key roles in leukocyte trafficking and are also
implicated in cancer metastasis to specific organs. Here we show that mouse B16F10 …

CXCR4, the receptor for the chemokine stromal cell-derived factor (SDF)-1 (CXCL12), is
involved in lymphocyte trafficking. We have demonstrated previously that it is required for …

The evolutionarily conserved chemokine superfamily encodes small peptide molecules that
bind G‐protein‐coupled receptors. In humans, this superfamily includes at least 46 ligands …

Background The expression of CXCR4 has been implicated in metastatic dissemination in
different models of breast cancer and melanoma. In the present study, we evaluated CXCR4 …