Introduction Skeletal metastases from breast adenocarcinoma are responsible for most of
the morbidity and mortality associated with this tumor and represent a significant and unmet …

Chemokines and their receptors play key roles in leukocyte trafficking and are also
implicated in cancer metastasis. We previously demonstrated that forced expression of …

Chemokines and their receptors function in migration and homing of cells to target tissues.
Recent evidence suggests that cancer cells use a chemokine receptor axis for metastasis …

Signals from the microenvironment have a profound influence on the maintenance and/or
progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived …

Liver and lung metastases are the predominant cause of colorectal cancer (CRC)-related
mortality. Recent research has indicated that CXCR3/chemokines interactions that …

The chemokines and their receptors are a superfamily of small secreted molecules that
control the migration of many cell types in the body. Several years ago it became clear that …

CXCR2 in non–small cell lung cancer (NSCLC) has been studied mainly in stromal cells
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …

Purpose: The chemokine receptors CCR7 and CXCR4 have been shown to play an
important role in cancer metastasis. We therefore studied the differential expression of …

The chemokine receptor CXCR4 belongs to the large superfamily of G-protein-coupled
receptors, and is directly involved in a number of biological processes including …

Background Metastasis, the spread and growth of tumor cells to distant organ sites,
represents the most devastating attribute and plays a major role in the morbidity and …