Ferroptosis and its potential role in the nervous system diseases

Y Zhou, W Lin, T Rao, J Zheng, T Zhang… - Journal of …, 2022 - Taylor & Francis
Ferroptosis is a novel regulated cell death characterized by metabolic disorders and iron-
dependent oxidative destruction of the lipid bilayer. It is primarily caused by the imbalance of …

Ferroptosis: An emerging therapeutic target in stroke

Y Liu, Y Fang, Z Zhang, Y Luo, A Zhang… - Journal of …, 2022 - Wiley Online Library
Stroke is a disastrous neurological disease with high morbidity and mortality. The
mechanism of the pathological process is extremely complicated and unclear. Although …

γ-Glutamylcysteine exerts neuroprotection effects against cerebral ischemia/reperfusion injury through inhibiting lipid peroxidation and ferroptosis

R Zhang, J Lei, L Chen, Y Wang, G Yang, Z Yin, L Luo - Antioxidants, 2022 - mdpi.com
Ferroptosis is a non-apoptotic form of cell death driven by iron-dependent lipid peroxidation.
Recent evidence indicates that inhibiting ferroptosis could alleviate cerebral …

Ferroptosis in brain microvascular endothelial cells mediates blood-brain barrier disruption after traumatic brain injury

J Fang, Q Yuan, Z Du, M Fei, Q Zhang, L Yang… - Biochemical and …, 2022 - Elsevier
Ferroptosis is a newly recognized form of regulated cell death. Recently, growing evidence
has shown that ferroptosis is involved in the pathogenesis of traumatic brain injury (TBI) …

Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation

Y Li, Y Liu, P Wu, Y Tian, B Liu, J Wang, J Bihl… - Cellular and Molecular …, 2021 - Springer
Subarachnoid hemorrhage (SAH) is a serious cerebrovascular disease with high mortality,
and the mean age at morbidity is younger than in other types of stroke. Early brain injury …

Mechanism of ferroptosis and its relationships with other types of programmed cell death: insights for potential interventions after intracerebral hemorrhage

SY Zhou, GZ Cui, XL Yan, X Wang, Y Qu… - Frontiers in …, 2020 - frontiersin.org
Intracerebral hemorrhage (ICH) is a fatal cerebrovascular disease with high morbidity and
mortality, for which no effective therapies are currently available. Brain tissue damage …

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

B Chen, Z Chen, M Liu, X Gao, Y Cheng, Y Wei… - Brain Research …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke because it has few viable
therapeutic options to intervene against primary or second brain injury. Recently, evidence …

Emerging role of ferroptosis in the pathogenesis of ischemic stroke: a new therapeutic target?

ZQ Bu, HY Yu, J Wang, X He, YR Cui, JC Feng… - ASN …, 2021 - journals.sagepub.com
Ischemic stroke is one of the main causes of high morbidity, mortality, and disability
worldwide; however, the treatment methods are limited and do not always achieve …

The emerging roles of ferroptosis in cells of the central nervous system

Y Li, D Xiao, X Wang - Frontiers in Neuroscience, 2022 - frontiersin.org
Ferroptosis is morphologically characterized by shrunken mitochondria and biochemically
characterized by iron overload, lipid peroxidation and lipid reactive oxygen species (ROS) …

Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models

SQ Gao, JQ Liu, YL Han, QZ Deji, WD Zhaba, HJ Deng… - Life sciences, 2020 - Elsevier
Background and purpose Early brain injury is an essential pathological process after
subarachnoid hemorrhage (SAH), with many cell death modalities. Ferroptosis is a newly …