Hydrophilic sugars for enhancing dissolution rate of cilostazol: effect of wet co-processing
Background: Cilostazol is an anti-platelets drug with considerable antithrombotic effects in
vivo. Therefore, it is widely used by elderly patients. However, it suffers from poor …
vivo. Therefore, it is widely used by elderly patients. However, it suffers from poor …
[HTML][HTML] Nanosuspension with improved saturated solubility and dissolution rate of cilostazol and effect of solidification on stability
I Aghrbi, V Fülöp, G Jakab, N Kállai-Szabó… - Journal of Drug Delivery …, 2021 - Elsevier
The aim of the study was to formulate cilostazol containing nanosuspension by top-down
wet milling method in order to increase the in vitro solubility and dissolution rate of this …
wet milling method in order to increase the in vitro solubility and dissolution rate of this …
Physical and dissolution characterization of cilostazol solid dispersions prepared by hot melt granulation (HMG) and thermal adhesion granulation (TAG) methods
YC Chen, HO Ho, JD Chiou, MT Sheu - International journal of …, 2014 - Elsevier
A growing number of poorly water-soluble drug have been discovered, but the poor
bioavailability is a critical problem. In this study, physical properties and dissolution profiles …
bioavailability is a critical problem. In this study, physical properties and dissolution profiles …
[PDF][PDF] Impact of the manufacturing technique on the dissolution-enhancement functionality of PEG4000 in Cilostazol tablets
O Sawafta, S Alhadid, IAA Awwad, E Migdadi… - …, 2021 - pharmacia.pensoft.net
Cilostazol was selected as poorly-soluble model drug to investigate the impact of the
manufacturing method on the excipient functionality of PEG4000 at various levels. Powder …
manufacturing method on the excipient functionality of PEG4000 at various levels. Powder …
Reprecipitation of poorly water-soluble cilostazol crystals using adsorbing carriers for enhanced dissolution and physicochemical modification
N Baek, GH Oh, C Park, TTT Tran, YJ Park, E Oh… - Journal of drug delivery …, 2018 - Elsevier
The aim of this new work was to improve the dissolution rate of poorly water-soluble
cilostazol (CLT) by adsorbing dissolved drug molecules onto the surface of undissolved …
cilostazol (CLT) by adsorbing dissolved drug molecules onto the surface of undissolved …
[PDF][PDF] Improved dissolution properties of ketoconazole through application of liquisolid techniques
S Singh, SS Shyale, HG Sandip - Int J Pharm Sci Nanotechnol …, 2015 - researchgate.net
In present investigation liquisolid compact technique is investigated as a tool for enhanced
dissolution of poorly water-soluble drug Ketoconazole. The liquisolid tablets were …
dissolution of poorly water-soluble drug Ketoconazole. The liquisolid tablets were …
Enhancement of solubility and dissolution of cilostazol by solid dispersion technique
JH Park, HK Choi - Archives of pharmacal research, 2015 - Springer
Cilostazol is practically insoluble in water and thus results in poor bioavailability. Only a few
approaches have been reported for improving the bioavailability of cilostazol. Solid …
approaches have been reported for improving the bioavailability of cilostazol. Solid …
Fabrication and evaluation of fast disintegrating pellets of cilostazol
U Arora, V Thakkar, L Baldaniya… - Drug Development and …, 2020 - Taylor & Francis
The present study was designed to formulate and develop fast disintegrating pellets of
poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline …
poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline …
Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol
KS Gouthami, D Kumar, R Thipparaboina… - International journal of …, 2015 - Elsevier
Improvement in dissolution of the drugs having poor solubility is a challenge in
pharmaceutical industry. Micronization is one technique, employed for dissolution …
pharmaceutical industry. Micronization is one technique, employed for dissolution …
Investigation of nanosized crystalline form to improve the oral bioavailability of poorly water soluble cilostazol
X Miao, C Sun, T Jiang, L Zheng… - … of Pharmacy & …, 2011 - journals.library.ualberta.ca
Purpose: The aim of this study was to develop cilostazol (CLT) nanocrystals intended to
improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT …
improve its dissolution rate and enhance its bioavailability. Methods: In this study, CLT …