Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

J Sodroski, WC Goh, C Rosen, K Campbell… - Nature, 1986 - nature.com
Acquired immune deficiency syndrome (AIDS) is characterized by marked depletion of the
T4+ helper subset of T cells1–3. The aetiological agent of the disease, the human T …

A molecular clone of HTLV-III with biological activity

AG Fisher, E Collalti, L Ratner, RC Gallo, F Wong-Staal - Nature, 1985 - nature.com
Acquired immune deficiency syndrome (AIDS) is an epidemic immunosuppressive disease
characteristically associated with a depletion of T lymphocytes of the helper/inducer …

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

JD Lifson, MB Feinberg, GR Reyes, L Rabin… - Nature, 1986 - nature.com
Formation of syncytia, with progression to cell death, is a characteristic feature of in vitro
cultures of susceptible cells infected with human T-lymphotropic virus type …

Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

RA Weiss, PR Clapham, R Cheingsong-Popov… - Nature, 1985 - nature.com
Human T-lymphotropic virus type III (LAV, HTLV-III) 1, 2 is aetiologically linked to acquired
immune deficiency syndrome (AIDS) and persistent general lymphadenopathy (PGL) 2–7 …

Molecular cloning and characterization of the HTLV-III virus associated with AIDS

BH Hahn, GM Shaw, SK Arya, M Popovic, RC Gallo… - Nature, 1984 - nature.com
We recently reported the isolation and characterization of a novel human T-lymphotropic
retrovirus, HTLV-III, in patients with acquired immune deficiency syndrome (AIDS) and in …

HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex

M Robert-Guroff, M Brown, RC Gallo - Nature, 1985 - nature.com
The isolation of the human T-cell leukaemia (lymphotropic) virus type III (HTLV-III or
lymphadenopathy-associated virus) from cells of many patients with acquired immune …

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

D Klatzmann, E Champagne, S Chamaret, J Gruest… - Nature, 1984 - nature.com
Many viruses, including retroviruses, are characterized by their specific cell tropism1–3.
Lymphadenopathy-associated virus (LAV) is a human lymphotropic retrovirus isolated from …

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

S Chakrabarti, M Robert-Guroff, F Wong-Staal… - Nature, 1986 - nature.com
The discovery that the aetiological agent of acquired immune deficiency syndrome (AIDS) is
a retro virus, referred to as human T-lymphotropic virus type III (HTLV-III) or …

Direct activation of resting T lymphocytes by human T-lymphotropic virus type I

L Gazzolo, MD Dodon - Nature, 1987 - nature.com
The mitogenic or antigenic stimulation of T lymphocytes in the presence of accessory cells
results in the synthesis of interleukin-2 (IL-2), which, on interacting with de novo synthesized …

Aetiology of AIDS—antibodies to human T-cell leukaemia virus (type III) in haemophiliacs

LW Kitchen, F Barin, JL Sullivan, MF McLane… - Nature, 1984 - nature.com
Human T-cell leukaemia virus type III (HTLV–III) is suspected of having a key role in the
pathogenesis of acquired immune deficiency syndrome (AIDS) 1–4. Epidemiological data …