We previously reported a monoclonal antibody named IF-43 that specifically recognizes
thrombin-modified fibrinogen (desAA-and desAABB-fibrin monomer) bound with fibrinogen …

INTRODUCTION: The presence of soluble fibrin (SF) provides evidence of thrombin
activation in the blood; therefore, SF is a useful marker for diagnosing blood coagulation …

BACKGROUND: Fibrin monomer (FM) and its complex (sFC) exist at high concentrations in
hypercoagulable state blood. Two novel immunoassays for sFC (SF and FMC) using specific …

Pooled plasma from 40 patients with severe disseminated intravascuiar coagulation (DIC)
secondary to septic conditions was subjected to gel permeation chromatography on …

Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a
battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated …

Background: Soluble fibrin (SF), composed of fibrin monomer (FM) and fibrinogen, is well
known to exist in the circulating blood derived from patients with thrombotic diseases, and its …

Plasma‐soluble fibrin monomer (SFM) level in patients with disseminated intravascular
coagulation (DIC) was significantly higher than the level in patients with pre‐DIC or in non …

Background: Soluble fibrin complex (SFC), composed of fibrin monomer and fibrinogen
derivatives, is known to exist in the circulating blood in patients with thrombosis. Its detection …

D-dimer is a stable, terminal product of fibrin degradation in plasma. In the 1970s, Gaffney
and colleagues introduced the concept of D-dimer measurement as a biomarker of …

Abstract Recently, monoclonal antibody (DD-3B6) to fibrin D-dimer was prepared and
coupled to latex beads to provide a specific test (Dimertest®) for fibrinolysis. The purpose of …