Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV
High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …
[HTML][HTML] Sialyl-LewisX glycoantigen is enriched on cells with persistent HIV transcription during therapy
F Colomb, LB Giron, L Kuri-Cervantes, OS Adeniji… - Cell reports, 2020 - cell.com
A comprehensive understanding of the phenotype of persistent HIV-infected cells,
transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure …
transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure …
Breaking the glyco-code of HIV persistence and immunopathogenesis
Purpose of review Glycoimmunology is an emerging field focused on understanding how
immune responses are mediated by glycans (carbohydrates) and their interaction with …
immune responses are mediated by glycans (carbohydrates) and their interaction with …
Sweet tasting chips: microarray-based analysis of glycans
Glycosylation, a ubiquitous post-translational modification of proteins and lipids that
generates enormous functional diversity, is rapidly gaining attention in the postgenomic era …
generates enormous functional diversity, is rapidly gaining attention in the postgenomic era …
Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers
Glycosylation is among the most complex posttranslational modifications with an extremely
high level of diversity that has made it refractory to high-throughput analyses. Despite its …
high level of diversity that has made it refractory to high-throughput analyses. Despite its …
[HTML][HTML] Decoding glycomics with a suite of methods for differential expression analysis
Glycomics, the comprehensive profiling of all glycan structures in samples, is rapidly
expanding to enable insights into physiology and disease mechanisms. However, glycan …
expanding to enable insights into physiology and disease mechanisms. However, glycan …
[HTML][HTML] Deep learning explains the biology of branched glycans from single-cell sequencing data
Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …
functional significance of various types of glycosylation at cellular levels is hard to unravel …
[HTML][HTML] Human galectin-9 is a potent mediator of HIV transcription and reactivation
M Abdel-Mohsen, L Chavez, R Tandon… - PLoS …, 2016 - journals.plos.org
Identifying host immune determinants governing HIV transcription, latency and infectivity in
vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 …
vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 …
A focused microarray approach to functional glycomics: transcriptional regulation of the glycome
EM Comelli, SR Head, T Gilmartin, T Whisenant… - …, 2006 - academic.oup.com
Glycosylation is the most common posttranslational modification of proteins, yet genes
relevant to the synthesis of glycan structures and function are incompletely represented and …
relevant to the synthesis of glycan structures and function are incompletely represented and …
A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome
KT Pilobello, DE Slawek… - Proceedings of the …, 2007 - National Acad Sciences
Glycosylation creates an intricate and complex code for biological information that plays a
role in cell–cell communication, infection, and immunity among many biological events …
role in cell–cell communication, infection, and immunity among many biological events …