Incorporation of a biocompatible nanozyme in cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model

A Adhikari, S Mondal, M Das, P Biswas… - Advanced …, 2021 - Wiley Online Library
The potentiality of nano‐enzymes in therapeutic use has directed contemporary research to
develop a substitute for natural enzymes, which are suffering from several disadvantages …

Nanozyme-based strategies for efficient theranostics of brain diseases

R Xu, S Zhang, P Wang, R Zhang, P Lin, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

Catalytic nanozymes for central nervous system disease

K Chen, S Sun, J Wang, XD Zhang - Coordination Chemistry Reviews, 2021 - Elsevier
The central nervous system (CNS) is a centralized control system for the human body, and
minor lesions or injuries will cause inestimable consequences. Due to high oxygen …

Nanozyme enabled protective therapy for neurological diseases

F Cheng, S Kotha, M Fu, Q Yang, H Wang, W He… - Nano Today, 2024 - Elsevier
Nanozymes are nanomaterials that mimic enzymatic activities found in natural human
biological processes. Nanozymes can perform reactive oxidative species (ROS) scavenging …

Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers

Y Zhang, A Khalique, X Du, Z Gao, J Wu… - Advanced …, 2021 - Wiley Online Library
Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …

Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson's disease-like symptoms

H Xu, X Ding, L Li, Q Li, Z Li, H Lin - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Parkinson's disease (PD), as the second most common neurodegenerative disease after
Alzheimer's, has become intractable with the increasing aging global population. The …

Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Y Ai, J You, J Gao, J Wang, H Sun, M Ding, Q Liang - Nano Research, 2021 - Springer
Oxidative stress is associated with many acute and chronic inflammatory diseases.
Development of nanomaterial-based enzyme mimetics for reactive oxygen species (ROS) …

A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

N Singh, MA Savanur, S Srivastava… - Angewandte …, 2017 - Wiley Online Library
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to
their therapeutic potential for the treatment of various diseases. Herein, we report that a …

A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system

N Singh, MA Savanur, S Srivastava, P D'Silva… - Nanoscale, 2019 - pubs.rsc.org
Biocompatible nanoparticles with an intrinsic ability to mimic the cellular antioxidant
enzymes are potential candidates for the development of new therapeutics for various …

Bioactive material-based nanozymes with multifunctional attributes for biomedicine: expanding antioxidant therapeutics for neuroprotection, cancer, and anti …

DO Lopez-Cantu, RB González-González… - Coordination Chemistry …, 2022 - Elsevier
Considering the biochemical rationale, the deployments of enzymes as therapeutic targets
against several oxidative stress-related diseases have been hindered by the limitations of …