Incorporation of a biocompatible nanozyme in cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model
The potentiality of nano‐enzymes in therapeutic use has directed contemporary research to
develop a substitute for natural enzymes, which are suffering from several disadvantages …
develop a substitute for natural enzymes, which are suffering from several disadvantages …
Nanozyme-based strategies for efficient theranostics of brain diseases
R Xu, S Zhang, P Wang, R Zhang, P Lin, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …
progression of various brain diseases, arising from either increased generation of reactive …
Catalytic nanozymes for central nervous system disease
The central nervous system (CNS) is a centralized control system for the human body, and
minor lesions or injuries will cause inestimable consequences. Due to high oxygen …
minor lesions or injuries will cause inestimable consequences. Due to high oxygen …
Nanozyme enabled protective therapy for neurological diseases
Nanozymes are nanomaterials that mimic enzymatic activities found in natural human
biological processes. Nanozymes can perform reactive oxidative species (ROS) scavenging …
biological processes. Nanozymes can perform reactive oxidative species (ROS) scavenging …
Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers
Y Zhang, A Khalique, X Du, Z Gao, J Wu… - Advanced …, 2021 - Wiley Online Library
Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …
Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson's disease-like symptoms
H Xu, X Ding, L Li, Q Li, Z Li, H Lin - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Parkinson's disease (PD), as the second most common neurodegenerative disease after
Alzheimer's, has become intractable with the increasing aging global population. The …
Alzheimer's, has become intractable with the increasing aging global population. The …
Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation
Y Ai, J You, J Gao, J Wang, H Sun, M Ding, Q Liang - Nano Research, 2021 - Springer
Oxidative stress is associated with many acute and chronic inflammatory diseases.
Development of nanomaterial-based enzyme mimetics for reactive oxygen species (ROS) …
Development of nanomaterial-based enzyme mimetics for reactive oxygen species (ROS) …
A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to
their therapeutic potential for the treatment of various diseases. Herein, we report that a …
their therapeutic potential for the treatment of various diseases. Herein, we report that a …
A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system
Biocompatible nanoparticles with an intrinsic ability to mimic the cellular antioxidant
enzymes are potential candidates for the development of new therapeutics for various …
enzymes are potential candidates for the development of new therapeutics for various …
Bioactive material-based nanozymes with multifunctional attributes for biomedicine: expanding antioxidant therapeutics for neuroprotection, cancer, and anti …
DO Lopez-Cantu, RB González-González… - Coordination Chemistry …, 2022 - Elsevier
Considering the biochemical rationale, the deployments of enzymes as therapeutic targets
against several oxidative stress-related diseases have been hindered by the limitations of …
against several oxidative stress-related diseases have been hindered by the limitations of …