Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Background Studies in rheumatoid arthritis synovial fibroblasts (RASF) demonstrated the
expression of several transient receptor potential channels (TRP) such as TRPV1, TRPV2 …

The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP
superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate …

A rapidly growing area of interest in biomedical science involves the reciprocal crosstalk
between the sensory nervous and immune systems. Both of these systems are highly …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …

Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel gated by
noxious heat, vanilloids and extracellular protons. TRPV1 acts as an important signal …

The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …

Despite significant progress in our understanding of the cellular and molecular mechanisms
underlying sensory transduction and nociception, clinical pain management remains a …

Background We have shown functional expression of several TRP channels on human
synovial cells, proposing significance in known calcium dependent proliferative and …