Shared genetic mechanism between type 2 diabetes and COVID-19 using pathway-based association analysis

KCH Wu, Q He, AN Bennett, J Li, KHK Chan - Frontiers in genetics, 2022 - frontiersin.org
Recent studies have shown that, compared with healthy individuals, patients with type 2
diabetes (T2D) suffer a higher severity and mortality of COVID-19. When infected with this …

Shared genetic architecture between type 2 diabetes and COVID-19 severity

J Ni, LJ Qiu, KJ Yin, GM Chen, HF Pan - Journal of endocrinological …, 2023 - Springer
Purpose Patients with type 2 diabetes (T2D) have demonstrated a higher risk for developing
more severe cases of COVID-19, but the complex genetic mechanism between them is still …

Bidirectional causal associations between type 2 diabetes and COVID‐19

H Cao, A Baranova, X Wei, C Wang… - Journal of Medical …, 2023 - Wiley Online Library
Observational studies have reported high comorbidity between type 2 diabetes (T2D) and
severe COVID‐19. However, the causality between T2D and COVID‐19 has yet to be …

Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank

A Lee, J Seo, S Park, Y Cho, G Kim, J Li… - Communications …, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is known as one of the important risk factors for the severity
and mortality of COVID-19. Here, we evaluate the impact of T2D and its genetic susceptibility …

Identification of common genes and pathways between type 2 diabetes and COVID-19

Y Wang, K Li, S Mo, P Yao, J Zeng, S Lu, S Qin - Frontiers in Genetics, 2024 - frontiersin.org
Background: Numerous studies have reported a high incidence and risk of severe illness
due to coronavirus disease 2019 (COVID-19) in patients with type 2 diabetes (T2DM) …

When type II diabetes mellitus meets COVID‐19—Identification of the shared gene signatures and biological mechanism between the two diseases

T Zhao, JP Ding, Z Liang, X Cui, K He… - European Journal of …, 2023 - Wiley Online Library
Background According to current studies, more than 20% of all patients diagnosed with
COVID‐19 globally have diabetes. Further, the mortality rate of these patients is 7.3 …

[HTML][HTML] Potential genes associated with COVID-19 and comorbidity

S Feng, F Song, W Guo, J Tan, X Zhang… - … journal of medical …, 2022 - ncbi.nlm.nih.gov
Hypertension, diabetes mellitus, and coronary artery disease are common comorbidities and
dangerous factors for infection and serious COVID-19. Polymorphisms in genes associated …

Causal associations between type 1 diabetes and COVID-19 infection and prognosis: a two-sample Mendelian randomization study

XL Ma, QY Shi, QG Zhao, Q Xu, SS Yan… - BMJ Open Diabetes …, 2023 - drc.bmj.com
Introduction It has been suggested that type 1 diabetes was associated with increased
COVID-19 morbidity and mortality. However, their causal relationship is still unclear. Herein …

Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent

FR Wendt, A De Lillo, GA Pathak, F De Angelis… - Frontiers in …, 2021 - frontiersin.org
Risk factors and long-term consequences of COVID-19 infection are unclear but can be
investigated with large-scale genomic data. To distinguish correlation from causation, we …

Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes and in over 1 million participants

FR Wendt, A De Lillo, GA Pathak, F De Angelis… - medRxiv, 2020 - medrxiv.org
To distinguish correlation from causation, we performed in-silico analyses of three COVID-
19 outcomes (N> 1,000,000). We show genetic correlation and putative causality with …