[HTML][HTML] The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis

I González-Mariscal, A Martin-Montalvo… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Coenzyme Q 10 (CoQ 10) is a redox molecule critical for the proper function of
energy metabolism and antioxidant defenses. Despite its essential role in cellular …

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast

A Martín-Montalvo, I González-Mariscal… - Journal of Biological …, 2013 - ASBMB
The study of the components of mitochondrial metabolism has potential benefits for health
span and lifespan because the maintenance of efficient mitochondrial function and …

[HTML][HTML] Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast

I González-Mariscal, A Martín-Montalvo… - Microbial Cell, 2017 - ncbi.nlm.nih.gov
Coenzyme Q is an essential lipid with redox capacity that is present in all organisms. In
yeast its biosynthesis depends on a multiprotein complex in which Coq7 protein has both …

Ptc7p dephosphorylates select mitochondrial proteins to enhance metabolic function

X Guo, NM Niemi, PD Hutchins, SGF Condon… - Cell reports, 2017 - cell.com
Proper maintenance of mitochondrial activity is essential for metabolic homeostasis.
Widespread phosphorylation of mitochondrial proteins may be an important element of this …

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

NM Niemi, GM Wilson, KA Overmyer, FN Vögtle… - Nature …, 2019 - nature.com
Mitochondrial proteins are replete with phosphorylation, yet its functional relevance remains
largely unclear. The presence of multiple resident mitochondrial phosphatases, however …

The antioxidant role of non-mitochondrial CoQ10: mystery solved!

MM Santoro - Cell metabolism, 2020 - cell.com
Although confirmed as the primary lipophilic antioxidant molecule endogenously produced
by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently …

Metabolic targets of coenzyme Q10 in mitochondria

A Hidalgo-Gutiérrez, P González-García… - Antioxidants, 2021 - mdpi.com
Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and
key component of the mitochondrial respiratory chain. For this second function, CoQ …

[HTML][HTML] Coenzyme Q10 supplementation–In ageing and disease

J Aaseth, J Alexander, U Alehagen - Mechanisms of Ageing and …, 2021 - Elsevier
Abstract Coenzyme Q 10 (CoQ 10) is an essential component of the mitochondrial electron
transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells …

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

NM Niemi, LR Serrano, LK Muehlbauer… - Nature …, 2023 - nature.com
PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper
mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant …

PGC1s and beyond: Disentangling the complex regulation of mitochondrial and cellular metabolism

L Coppi, S Ligorio, N Mitro, D Caruso… - International Journal of …, 2021 - mdpi.com
Metabolism is the central engine of living organisms as it provides energy and building
blocks for many essential components of each cell, which are required for specific functions …