[HTML][HTML] The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis
I González-Mariscal, A Martin-Montalvo… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Coenzyme Q 10 (CoQ 10) is a redox molecule critical for the proper function of
energy metabolism and antioxidant defenses. Despite its essential role in cellular …
energy metabolism and antioxidant defenses. Despite its essential role in cellular …
The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast
A Martín-Montalvo, I González-Mariscal… - Journal of Biological …, 2013 - ASBMB
The study of the components of mitochondrial metabolism has potential benefits for health
span and lifespan because the maintenance of efficient mitochondrial function and …
span and lifespan because the maintenance of efficient mitochondrial function and …
[HTML][HTML] Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast
I González-Mariscal, A Martín-Montalvo… - Microbial Cell, 2017 - ncbi.nlm.nih.gov
Coenzyme Q is an essential lipid with redox capacity that is present in all organisms. In
yeast its biosynthesis depends on a multiprotein complex in which Coq7 protein has both …
yeast its biosynthesis depends on a multiprotein complex in which Coq7 protein has both …
Ptc7p dephosphorylates select mitochondrial proteins to enhance metabolic function
Proper maintenance of mitochondrial activity is essential for metabolic homeostasis.
Widespread phosphorylation of mitochondrial proteins may be an important element of this …
Widespread phosphorylation of mitochondrial proteins may be an important element of this …
Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation, yet its functional relevance remains
largely unclear. The presence of multiple resident mitochondrial phosphatases, however …
largely unclear. The presence of multiple resident mitochondrial phosphatases, however …
The antioxidant role of non-mitochondrial CoQ10: mystery solved!
MM Santoro - Cell metabolism, 2020 - cell.com
Although confirmed as the primary lipophilic antioxidant molecule endogenously produced
by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently …
by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently …
Metabolic targets of coenzyme Q10 in mitochondria
A Hidalgo-Gutiérrez, P González-García… - Antioxidants, 2021 - mdpi.com
Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and
key component of the mitochondrial respiratory chain. For this second function, CoQ …
key component of the mitochondrial respiratory chain. For this second function, CoQ …
[HTML][HTML] Coenzyme Q10 supplementation–In ageing and disease
J Aaseth, J Alexander, U Alehagen - Mechanisms of Ageing and …, 2021 - Elsevier
Abstract Coenzyme Q 10 (CoQ 10) is an essential component of the mitochondrial electron
transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells …
transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells …
PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy
NM Niemi, LR Serrano, LK Muehlbauer… - Nature …, 2023 - nature.com
PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper
mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant …
mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant …
PGC1s and beyond: Disentangling the complex regulation of mitochondrial and cellular metabolism
L Coppi, S Ligorio, N Mitro, D Caruso… - International Journal of …, 2021 - mdpi.com
Metabolism is the central engine of living organisms as it provides energy and building
blocks for many essential components of each cell, which are required for specific functions …
blocks for many essential components of each cell, which are required for specific functions …