Amyloidosis is primarily characterized by the deposition of misfolded protein aggregates.
Although the natural polyphenols have long been known as effective amyloid inhibitors, the …

Numerous studies demonstrate that natural polyphenols can inhibit amyloid formation and
disrupt preformed amyloid fibrils. In the present study, the fibril-disruptive effects of …

Green tea polyphenols (GTPs) are found to be potent inhibitors of amyloid fibril formation.
We report the effective inhibitory property of (−)-epicatechin gallate (ECG) during the alkali …

Amyloidoses represent a group of pathological conditions characterized by amyloid fibrils
accumulating in the form of deposits in intra-or extracellular space, leading to tissue …

At least twenty human proteins can fold abnormally to form pathological deposits that are
associated with several degenerative diseases. Despite extensive investigation on amyloid …

In the present study, we have investigated the effects of protein concentration and stirring on
the in vitro assembly of Hen Egg White Lysozyme (HEWL), particularly with regard to the …

Systemic amyloidosis is a hereditary disorder that mostly arises as a result of specific point
mutations to the wild type gene of lysozyme, forming mutant lysozyme variants leading to …

Epigallocatechin gallate (EGCG), the most abundant flavanoid in green tea, is currently
being evaluated in the clinic due to its benefits in the treatment of amyloid disorders. Its anti …

Natural polyphenols are major constituents of plant foods and herbs. Numerous studies
have demonstrated that natural polyphenols inhibited amyloid formation and destabilized …

Interaction of small molecule inhibitors with protein aggregates has been studied
extensively, but how these inhibitors modulate aggregation kinetic parameters is little …