Gene repair involving the induction of double-stranded DNA cleavage at a chromosomal target site
A Choulika, R Mulligan - US Patent App. 09/917,295, 2002 - Google Patents
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal
DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a …
DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a …
Gene repair involving in vivo excision of targeting DNA
A Choulika, RC Mulligan - US Patent 7,285,538, 2007 - Google Patents
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents …
US7285538B2 - Gene repair involving in vivo excision of targeting DNA - Google Patents …
Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
A Choulika, RC Mulligan - US Patent 9,458,439, 2016 - Google Patents
US9458439B2 - Chromosomal modification involving the induction of double-stranded DNA
cleavage and homologous recombination at the cleavage site - Google Patents US9458439B2 …
cleavage and homologous recombination at the cleavage site - Google Patents US9458439B2 …
Gene repair involving in vivo excision of targeting DNA
A Choulika, R Mulligan - US Patent App. 09/922,495, 2002 - Google Patents
The present invention is related to Applicants discovery that excision of targeting or
correcting DNA from a vector within cells which have taken up the vector Sig nificantly …
correcting DNA from a vector within cells which have taken up the vector Sig nificantly …
Gene repair involving the induction of double-stranded DNA cleavage at a chromosomal target site
A Choulika, R Mulligan - US Patent App. 10/337,229, 2004 - Google Patents
The present invention is related to Applicants discovery that induction of double stranded
DNA cleavage at a specific Site in chromosomal DNA induces a cellular repair mechanism …
DNA cleavage at a specific Site in chromosomal DNA induces a cellular repair mechanism …
Use of chimeric nucleases to stimulate gene targeting
D Baltimore, M Porteus - US Patent 9,447,434, 2016 - Google Patents
Gene targeting is a technique to introduce genetic change into one or more specific
locations in the genome of a cell. For example, gene targeting can introduce genetic change …
locations in the genome of a cell. For example, gene targeting can introduce genetic change …
Methods and compositions for inactivation of dihydrofolate reductase
T Collingwood - US Patent App. 11/804,222, 2008 - Google Patents
BACKGROUND 0004 Various methods and compositions for targeted cleavage of genomic
DNA have been described. Such tar geted cleavage events can be used, for example, to …
DNA have been described. Such tar geted cleavage events can be used, for example, to …
Methods and compositions for targeted single-stranded cleavage and targeted integration
J Wang - US Patent 10,113,207, 2018 - Google Patents
US10113207B2 - Methods and compositions for targeted single-stranded cleavage and
targeted integration - Google Patents US10113207B2 - Methods and compositions for …
targeted integration - Google Patents US10113207B2 - Methods and compositions for …
Methods and compositions for targeted single-stranded cleavage and targeted integration
J Wang - US Patent 9,631,186, 2017 - Google Patents
US9631186B2 - Methods and compositions for targeted single-stranded cleavage and
targeted integration - Google Patents US9631186B2 - Methods and compositions for targeted …
targeted integration - Google Patents US9631186B2 - Methods and compositions for targeted …
Delivery methods and compositions for nuclease-mediated genome engineering
GK Lee, BE Riley, SJS Martin, T Wechsler - 2017 - Google Patents
targeted cleavage events can be used, for example, to induce targeted mutagenesis, induce
targeted deletions of cellular DNA sequences, and facilitate targeted recombination at a …
targeted deletions of cellular DNA sequences, and facilitate targeted recombination at a …