Respiratory disorders like asthma, emphysema, and pulmonary fibrosis affect millions of
Americans and many more worldwide. Despite advancements in medical research that have …

Animal models of disease serve a vital function in the search for novel therapeutic
approaches. While these systems cannot replicate human disease, they can be used to …

MODELING OF HUMAN DISEASE in animals forms the basis of much of biomedical
research. Animal models have been used to explore normal physiology, the …

The 2nd Cross Company Respiratory Symposium (CCRS), held in Horsham, UK in 2012,
brought together representatives from across the pharmaceutical industry with expert …

Experimental models are critical for the understanding of lung health and disease and are
indispensable for drug development. However, the pathogenetic and clinical relevance of …

Genetic manipulation in mice often combined with models of human disease has allowed
investigators to dissect specific disease pathways. These tools have taught us much about …

Gene targeting in mice (transgenic and knockout) has provided investigators with an
unparalleled armamentarium in recent decades to dissect the cellular and molecular basis …

The laboratory mouse Mus musculus has long been used as a model organism to test
hypotheses and treatments related to understanding the mechanisms of disease in humans; …

Animal modeling has been essential to the development of every drug used to treat asthma
and chronic obstructive pulmonary disease (COPD). Determining the safety and efficacy of …

Recent advances in mouse models of experimental asthma coupled with vast improvements
in systems that assess respiratory physiology have considerably increased the accuracy and …