Summary Inflammatory NF-κB/RelA activation is mediated by the three canonical inhibitors,
IκBα,-β, and-ɛ. We report here the characterization of a fourth inhibitor, nfκb2/p100, that …

The nuclear factor kappaB (NF-κB) family of transcription factors consists of 15 possible
dimers whose activity is controlled by a family of inhibitor proteins, known as IκBs. A variety …

The NF-κB signaling pathway regulates the activity of multiple dimeric transcription factors
that are generated from five distinct monomers. The availabilities of specific dimers are …

Abstract The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the
regulation of numerous biological processes including development of the immune system …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐
component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK …

▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an
exciting and active area of study. The involvement of NF-κB in the expression of numerous …

The eukaryotic transcription factor NF-κB plays a central role in the induced expression of
human immunodeficiency virus type 1 and in many aspects of the genetic program …

The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the
transcriptional responses of physiological processes that include cell division, cell survival …

The dramatic difference between healthy and acutely or chronically inflamed tissue is due to
the new expression of a host of proteins not normally needed by the organism. Many of the …