Deciphering the multicomponent synergy mechanisms of SiNiSan prescription on irritable bowel syndrome using a bioinformatics/network topology based strategy

B Li, J Rui, X Ding, Y Chen, X Yang - Phytomedicine, 2019 - Elsevier
Background SiNiSan (SNS) is a traditional Chinese medicine (TCM) prescription that has
been widely used in the clinical treatment of irritable bowel syndrome (IBS). However, the …

The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis

Y Tang, H Su, H Wang, F Lu, K Nie, Z Wang… - Molecular …, 2021 - Springer
Background The incidence of diabetes mellitus (DM) and depression is increasing year by
year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan …

Revealing the synergistic mechanism of multiple components in compound fengshiding capsule for rheumatoid arthritis therapeutics by network pharmacology

H Duan, K Zhai, GJ Khan, J Zhou, T Cao… - Current molecular …, 2019 - ingentaconnect.com
Background: Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal
origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and …

Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata

N Zhu, J Hou, N Yang - Scientific Reports, 2021 - nature.com
Inflammation is a key factor in the development and complications of various diseases
because it has a complex pathogenesis. Andrographis paniculate (Burm. f.) Nees (Chuan …

Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice

L Xu, J Cheng, J Lu, G Lin, Q Yu, Y Li, J Chen… - Frontiers in …, 2022 - frontiersin.org
Hyperuricemia (HUA), a common metabolic disease, is treated as the second-largest
metabolic disease after diabetes in China. Cortex Phellodendri (CP) is one of the most …

The active compounds and therapeutic mechanisms of pentaherbs formula for oral and topical treatment of atopic dermatitis based on network pharmacology

M Chu, MSM Tsang, R He, CWK Lam, ZB Quan… - Plants, 2020 - mdpi.com
To examine the molecular targets and therapeutic mechanism of a clinically proven Chinese
medicinal pentaherbs formula (PHF) in atopic dermatitis (AD), we analyzed the active …

A Systems Biology‐Based Investigation into the Pharmacological Mechanisms of Wu Tou Tang Acting on Rheumatoid Arthritis by Integrating Network Analysis

Y Zhang, D Wang, S Tan, H Xu, C Liu… - Evidence‐Based …, 2013 - Wiley Online Library
Aim. To investigate pharmacological mechanisms of Wu Tou Tang acting on rheumatoid
arthritis (RA) by integrating network analysis at a system level. Methods and Results. Drug …

Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn's Disease

SY Suh, WG An - Evidence‐Based Complementary and …, 2017 - Wiley Online Library
In East Asian traditional medicine, Pulsatillae Radix (PR) is widely used to treat amoebic
dysentery and renowned for its anti‐inflammatory effects. This study aimed to confirm …

Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus

M Adnan, BB Jeon, MHU Chowdhury, KK Oh, T Das… - Life, 2022 - mdpi.com
Caesalpinia sappan L.(CS) is widely used to treat diabetic complications in south-east Asia,
specifically in traditional Chinese medicine. This study intends to explain the molecular …

Isolation and identification of the components in Cybister chinensis Motschulsky against inflammation and their mechanisms of action based on network pharmacology …

YH Che, ZR Xu, LL Ni, XX Dong, ZZ Yang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Cybister chinensis Motschulsky belongs to the family
Dytiscidae. As a traditional Chinese medicine, the insect is called Longshi in the folk and is …