Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
Chemokine CXCL12 and receptor CXCR4 control multiple steps in primary tumor growth
and metastasis in breast cancer and more than 20 other human malignancies. Mechanisms …
and metastasis in breast cancer and more than 20 other human malignancies. Mechanisms …
CXCL12-γ in primary tumors drives breast cancer metastasis
P Ray, AC Stacer, J Fenner, SP Cavnar, K Meguiar… - Oncogene, 2015 - nature.com
Compelling evidence shows that chemokine CXC motif chemokine ligand 12 (CXCL12)
drives metastasis in multiple malignancies. Similar to other key cytokines in cancer, CXCL12 …
drives metastasis in multiple malignancies. Similar to other key cytokines in cancer, CXCL12 …
CXCR4 regulates growth of both primary and metastatic breast cancer
The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
[HTML][HTML] CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis
Y Sun, X Mao, C Fan, C Liu, A Guo, S Guan, Q Jin, B Li… - Tumor Biology, 2014 - Springer
CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of
cancer cells. They have been shown to play an important role in regulating metastasis of …
cancer cells. They have been shown to play an important role in regulating metastasis of …
Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands
CXCR7 is a receptor for chemokines including CXCL12 (stromal-derived factor-1), a
molecule that promotes tumor growth and metastasis in breast cancer and other …
molecule that promotes tumor growth and metastasis in breast cancer and other …
CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model
X Ma, K Norsworthy, N Kundu, WH Rodgers… - Molecular cancer …, 2009 - AACR
Breast tumor cells express the chemokine receptor CXCR3, which binds the ligands CXCL9,
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …
CXCL10, and CXCL11. CXCR3 and other chemokine receptors may mediate tumor …
Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells
MK Wendt, AN Cooper, MB Dwinell - Oncogene, 2008 - nature.com
Expression of the chemokine receptor CXCR4 has been linked with increased metastasis
and decreased clinical prognosis in breast cancer. The current paradigm dictates that …
and decreased clinical prognosis in breast cancer. The current paradigm dictates that …
[HTML][HTML] Multiple functions of CXCL12 in a syngeneic model of breast cancer
SA Williams, Y Harata-Lee, I Comerford, RL Anderson… - Molecular cancer, 2010 - Springer
Background A growing body of work implicates chemokines, in particular CXCL12 and its
receptors, in the progression and site-specific metastasis of various cancers, including …
receptors, in the progression and site-specific metastasis of various cancers, including …
[HTML][HTML] CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity
Chemokines and chemokine receptors have critical roles in cancer metastasis and have
emerged as one of the targeting options in cancer therapy. However, the treatment efficacy …
emerged as one of the targeting options in cancer therapy. However, the treatment efficacy …
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
LJ Drury, JJ Ziarek, S Gravel… - Proceedings of the …, 2011 - National Acad Sciences
Chemokines and chemokine receptors are extensively and broadly involved in cancer
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …