Abstract γ′ Fibrinogen is an isoform of fibrinogen that normally constitutes about 7% of total
plasma fibrinogen, and arises from an alternative processing event in the γ chain mRNA. γ …

Background: Fibrinogen γ′, a fibrinogen γ‐chain variant generated via alternative mRNA
processing, has been associated with susceptibility to thrombotic disease. Objective: The …

Background: Studies of disease associations with γ′ fibrinogen, a newly emerging risk
factor for cardiovascular disease, have been hampered by the lack of a standardized and …

The γ'fibrinogen isoform produces clots that are stiffer and more resistant to breakdown than
the more common fibrinogen isoform, γA. Increased levels of γ'fibrinogen are associated …

Objective—γ′ fibrinogen is a newly emerging biomarker that is associated with
cardiovascular disease (CVD). However, the genetic determinants of γ′ fibrinogen levels …

Introduction Epidemiological studies generally have not found plasma total fibrinogen to be
a risk factor for venous thromboembolism (VTE), but several have reported associations …

INTRODUCTION: Fibrinogen is a major structural protein in blood clots, and is also a well-
known acute phase reactant. The γ chain gene of fibrinogen has two alternative splice …

Background Elevated plasma fibrinogen is associated with arterial thrombosis in humans
and promotes thrombosis in mice by increasing fibrin formation and thrombus fibrin content …

Objectives—To prospectively examine the association of plasma γ′ fibrinogen with the
incidence of multiple cardiovascular disease (CVD) end points, independent of established …

Introduction The association of gamma prime (γ′) fibrinogen; a fibrinogen γ chain variant
generated via alternative mRNA processing, with cardiovascular disease (CVD) remains …