Myeloid-derived suppressor cells (MDSCs) suppress antitumor immune activities and
facilitate cancer progression. Although the concept of immunosuppressive MDSCs is well …

Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is an RCC1 family
member and plays an essential role in mitosis. However, the roles of RCC2 in breast cancer …

Carcinoma‑associated fibroblasts (CAFs) are essential for initiating lung cancer cell invasion
and metastasis. An elevated MACC1 expression has been implicated in the progression of …

Objective: Ras-related C3 botulinum toxin substrate1 (Rac1) and epithelial mesenchymal
transition (EMT) are key therapeutic targets in cancer. We investigated the clinical …

The roles of microRNAs (miRNAs) in the occurrence, metastasis, and prognosis of lung
adenocarcinoma (LUAD) have been drawing extensive attention from researchers. The aim …

Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide
exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle …

Activation of CC chemokine receptor type 7 (CCR7) has been demonstrated to mediate the
occurrence and progression of non-small cell lung cancer (NSCLC). However, the potential …

Chemokines and chemokine receptors are causally involved in the metastasis of human
malignancies. As a crucial chemokine receptor for mediating immune homeostasis …

Increased levels of the chemokine CCL2 in cancer patients are associated with poor
prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory …

Recently, we identified a lung adenocarcinoma signature that segregated tumors into three
clades distinguished by histological invasiveness. Among the genes differentially expressed …