Telomerase counteracts telomere erosion that stems from incomplete chromosome end
replication and nucleolytic processing. A precise understanding of telomere length …

Extrachromosomal telomeric circles are commonly invoked as important players in telomere
maintenance, but their origin has remained elusive. Using electron microscopy analysis on …

Telomeres protect the ends of linear chromosomes from degradation and abnormal
recombination events, and in vertebrates may be important in cellular senescence and …

Abstract Over 60 years ago Barbara McClintock described the telomere and suggested that
it protected the chromosome from illegitimate or end-to-end fusion, thus functioning to …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Telomeres protect the ends of eukaryotic chromosomes from being recognized and
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Telomeres are stabilized, and telomeric DNA is replenished, by the action of the
ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the …

Telomere shortening impairs proliferation of transformed cells but also leads to cancer
initiation by inducing chromosomal instability. Here, we discuss recent developments in our …

Telomeres are complex nucleoprotein structures that protect the extremities of linear
chromosomes. Telomere replication is a major challenge because many obstacles to the …