In mammalian cells, activation of certain checkpoint pathways as a result of exposure to
genotoxic agents results in cell cycle arrest. The integrity of these arrest pathways is critical …

In the present study, we investigated the role of p53 in G2 checkpoint function by
determining the mechanism by which p53 prevents premature exit from G2 arrest after …

DNA-damaging agents induce accumulation of the tumor suppressor and G1 checkpoint
protein p53, leading cells to either growth arrest in G1 or apoptosis (programmed cell death) …

The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the
mammalian response to DNA damage. To identify the mechanism by which p53 regulates …

To maintain genome stability, cells with damaged DNA must arrest to allow repair of
mutations before replication. Although several key components required to elicit this arrest …

Damage-induced G1 checkpoint in mammalian cells involves upregulation of p53, which
activates transcription of p21 Waf1 (CDKN1A). Inhibition of cyclin-dependent kinase (CDK) 2 …

While p53 activity is critical for a DNA damage-induced G 1 checkpoint, its role in the G 2
checkpoint has not been compelling because cells lacking p53 retain the ability to arrest in …

Cell cycle checkpoints regulate progression through the cell cycle. In yeast, loss of the G2
checkpoint by mutation of the rad9 gene results in increased genetic instability as well as …

Exposure of cells to genotoxic agents results in activation of checkpoint pathways leading to
cell cycle arrest. These arrest pathways allow repair of damaged DNA before its replication …

The cell cycle regulatory tumor suppressor proteins p53 and pRB are targeted for
inactivation by several tumor viruses, including the high-risk types of human …