Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

Suppression during the early phases of the immune system often correlates directly with a
fatal outcome for the host. The ebolaviruses, some of the most lethal viruses known, appear …

Ebola viruses (EBOVs) cause rare but highly fatal outbreaks of viral hemorrhagic fever in
humans, and approved treatments for these infections are currently lacking. The Ebola VP35 …

Ebola virus (EBOV) infection blocks cellular production of alpha/beta interferon (IFN-α/β) and
the ability of cells to respond to IFN-α/β or IFN-γ. The EBOV VP35 protein has previously …

Ebola hemorrhagic fever is a rapidly progressing acute febrile illness characterized by high
virus replication, severe immunosuppression, and case fatalities of ca. 80%. Inhibition of …

We have identified a putative coiled-coil motif within the amino-terminal half of the
ebolavirus VP35 protein. Cross-linking studies demonstrated the ability of VP35 to form …

Ebolaviruses are causative agents of lethal hemorrhagic fever in humans and nonhuman
primates. Among the filoviruses characterized thus far, Reston Ebola virus (REBOV) is the …

Reston viruses are the only Ebolaviruses that are not pathogenic in humans. We analyzed
196 Ebolavirus genomes and identified specificity determining positions (SDPs) in all nine …

Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic
fever during sporadic outbreaks, and no approved treatments are currently available. The …

The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-α/β) and IFN-γ signaling
by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) …