Digital twinning of cardiac electrophysiology for congenital heart disease

M Salvador, F Kong, M Peirlinck… - Journal of the …, 2024 - royalsocietypublishing.org
In recent years, blending mechanistic knowledge with machine learning has had a major
impact in digital healthcare. In this work, we introduce a computational pipeline to build …

Deep learning-based emulation of human cardiac activation sequences

A Bertrand, J Camps, V Grau, B Rodriguez - International Conference on …, 2023 - Springer
The vision of digital twins for precision cardiology is to combine expert knowledge and data
of patients' cardiac pathophysiology with advanced computational methods, in order to …

Cardiac Digital Twin Pipeline for Virtual Therapy Evaluation

J Camps, ZJ Wang, R Doste, M Holmes… - arXiv preprint arXiv …, 2024 - arxiv.org
Cardiac digital twins are computational tools capturing key functional and anatomical
characteristics of patient hearts for investigating disease phenotypes and predicting …

Deep computational model for the inference of ventricular activation properties

L Li, J Camps, A Banerjee, M Beetz… - … Workshop on Statistical …, 2022 - Springer
Patient-specific cardiac computational models are essential for the efficient realization of
precision medicine and in-silico clinical trials using digital twins. Cardiac digital twins can …

Branched latent neural maps

M Salvador, AL Marsden - Computer Methods in Applied Mechanics and …, 2024 - Elsevier
Abstract We introduce Branched Latent Neural Maps (BLNMs) to learn finite dimensional
input–output maps encoding complex physical processes. A BLNM is defined by a simple …

Branched Latent Neural Operators

M Salvador, AL Marsden - arXiv preprint arXiv:2308.02599, 2023 - arxiv.org
We introduce Branched Latent Neural Operators (BLNOs) to learn input-output maps
encoding complex physical processes. A BLNO is defined by a simple and compact …

pyCEPS: A cross-platform Electroanatomic Mapping Data to Computational Model Conversion Platform for the Calibration of Digital Twin Models of Cardiac …

R Arnold, AJ Prassl, A Neic, F Thaler… - arXiv preprint arXiv …, 2024 - arxiv.org
Background and Objective: Data from electro-anatomical mapping (EAM) systems are
playing an increasingly important role in computational modeling studies for the patient …

Digital twinning of cardiac electrophysiology models from the surface ECG: a geodesic backpropagation approach

T Grandits, J Verhülsdonk, G Haase… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
The eikonal equation has become an indispensable tool for modeling cardiac electrical
activation accurately and efficiently. In principle, by matching clinically recorded and eikonal …

Whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations

M Salvador, M Strocchi, F Regazzoni… - NPJ Digital …, 2024 - nature.com
Cardiac digital twins provide a physics and physiology informed framework to deliver
personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to …

Personalized Topology-Informed 12-Lead ECG Electrode Localization from Incomplete Cardiac MRIs for Efficient Cardiac Digital Twins

L Li, H Smith, Y Lyu, J Camps, B Rodriguez… - arXiv preprint arXiv …, 2024 - arxiv.org
Cardiac digital twins (CDTs) offer personalized\textit {in-silico} cardiac representations for
the inference of multi-scale properties tied to cardiac mechanisms. The creation of CDTs …