Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide.
Despite its prevalence, our understanding of the underlying mechanisms remains …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

Transient receptor potential vanilloid (TRPV) 4 belongs to the TRPV subfamily of TRP ion
channels. TRPV4 channels play a critical role in chondrocytes and thus TRPV4 is an …

Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels
have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid …

Transient receptor potential channels (TRP channels) are cation selective transmembrane
receptors with diverse structures, activation mechanisms and physiological functions. TRP …

Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and
surrounding tissues, and is associated with both advanced age and joint injury …

Biomechanical factors play a critical role in regulating the physiology as well as the
pathology of multiple joint tissues and have been implicated in the pathogenesis of …

Objective Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+‐permeable channel
that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in …

Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …