Influx or efflux transporter (s), or both, are frequently involved in the intestinal absorption of
various therapeutic drugs. In the present study, the effects of altered gastric emptying rates …

The role of intestinal efflux transporters such as P-glycoprotein (P-gp), breast cancer
resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in intestinal …

Fluorouracil (5‐FU), an anticancer drug, causes severe gastrointestinal damage, which may
affect the absorption of orally administered drugs including the substrates of intestinal …

The absorption of oral drug in the intestine is an important factor to determine the drug
bioavailability. There are many intestinal transporters mediating drug absorption …

Purpose. The aim of the present study was to investigate the transport kinetics of intestinal
secretory processes in the jejunum, ileum and colon of rats and humans and in Caco-2 cells …

Purpose To study the correlation of intestinal absorption for drugs with various absorption
routes between human and rat, and to explore the underlying molecular mechanisms for the …

Objectives The aim of this research was to assess regional difference in the intestinal
absorption of ranitidine HCl as an indicator for the potential effect of P-glycoprotein (P-gp) …

Intestinal permeability (Peff) is one of the key biopharmaceutic parameters that determine
the in-vivo rate and extent of intestinal drug absorption in man and animals (Amidon et al …

Intestinal eχsorption of salicylic acid, urea and quinidine was measured during the perfusion
of the rat intestinal lumen with Tyrode solution. The intestinal clearance (CLi) of the three …

The purpose of this study was to evaluate the impact of intestinal efflux transporters on the in
vivo oral absorption process. Three model drugs—fexofenadine (FEX), sulfasalazine …