P-Glycoprotein (P-gp), an ATP-dependent efflux transporter, is expressed in brush-border
membranes in the intestines of humans and rodents. In this study, the fate of quinidine, a P …

Introduction: In pharmacotherapy, drugs are mostly taken orally to be absorbed systemically
from the small intestine, and some drugs are known to have preferential absorption sites in …

The intestinal transport of quinidine was characterized in rat small intestine, using the
Ussing‐type chamber under short‐circuited conditions. In the short‐circuited condition …

Background The potential absorption-limiting effect of intestinal efflux transporters such as P-
glycoprotein (P-gp) has been well recognized, primarily based on results of numerous Caco …

Abstract Tannergren, C. 2004. Intestinal permeability and presystemic Extraction of
Fexofenadine and R/SYverapamil. Acta Universitatis Upsaliensis. Comprehensive …

抄録 The absorption of drugs from the gastrointestinal tract is one of the important
determinants for oral bioavailability. Development of in vitro experimental techniques such …

Purpose. To investigate the membrane transport mechanisms of fexofenadine in the Caco-2
model. Methods. Transport studies were performed in Caco-2 cell monolayers 21-25 days …

Both influx and efflux transporters are thought to be involved in the intestinal absorption of
fexofenadine. The present study examined the influx transporter-mediated intestinal …

The small intestinal damage induced by the methotrexate (MTX) treatment results in
malabsorption and diarrhea. The fluoresceinated methotrexate (F-MTX) may possibly be …

Objective Our objective was to investigate the main in vivo transport mechanisms of
fexofenadine involved in the intestinal absorption and bioavailability of the drug in humans …