Abstract□ This review focuses on permeability measurements in humans, briefly discussing
different perfusion techniques, the relevance of human P eff values, and various aspects of …

Oral drug absorption is usually dependent on drug's physicochemical properties, formulation
design and physiological conditions of gastrointestinal tract [1]. It is well known that …

The purpose of this study was to investigate the role of P-gp efflux in the in vivo intestinal
absorption process of BCS class III P-gp substrates, ie high-solubility low-permeability …

Aim: To investigate the mechanisms underlying the intestinal absorption of the major
bioactive component forsythoside A (FTA) extracted from Forsythiae fructus. Methods: An in …

The purpose of this study was to examine drug absorption profile utilizing human intestinal
tissues from ulcerative colitis (UC) patients and to compare with normal tissues from …

The systemic clearance of many quinolone antibiotics is mainly via metabolism and urinary
excretion; by contrast, biliary excretion is a major route of elimination for a new quinolone …

Michael Mayersohn and Milo Gibaldi, Drug transport IV: Influence of hypotonic and
hypertonic solutions on passive drug transfer across the everted rat intestine, Journal of …

Purpose. To evaluate the effects of gut metabolism and efflux on drug absorption by
simulation studies using a pharmacokinetic model involving diffusion in epithelial cells …

Etoposide, an anti-neoplastic agent and a substrate of P-glycoprotein (P-gp), exhibits
variable oral bioavailability. P-gp, the multidrug resistance gene (mdr 1) product, has been …